{"id":1392,"date":"2023-07-17T20:42:45","date_gmt":"2023-07-17T18:42:45","guid":{"rendered":"https:\/\/andreaskalcker.com\/publicaciones-en-humanos\/"},"modified":"2025-05-12T13:06:53","modified_gmt":"2025-05-12T11:06:53","slug":"humane-studien-mit-cds","status":"publish","type":"page","link":"https:\/\/andreaskalcker.com\/de\/humane-studien-mit-cds\/","title":{"rendered":"Humane Studien mit CDS"},"content":{"rendered":"\t\t
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Humane Studien mit CDS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Auf Dioxipedia finden Sie eine sorgf\u00e4ltig kuratierte Auswahl von Links zu Forschungsstudien, die sich mit Chlordioxid befassen und einen direkten Bezug zu menschlichen Anwendungen haben.<\/p>


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Diese Zusammenstellung geht \u00fcber die industrielle Nutzung oder die Wasseraufbereitung hinaus und zielt darauf ab, einen umfassenden \u00dcberblick \u00fcber die wissenschaftliche Forschung zu den Auswirkungen von Chlordioxid und seinen m\u00f6glichen Nutzen f\u00fcr die menschliche Gesundheit zu geben.<\/p>\n

Diese Sammlung erhebt zwar keinen Anspruch auf Vollst\u00e4ndigkeit, enth\u00e4lt aber einige der bisher relevantesten und bedeutendsten wissenschaftlichen Studien \u00fcber Chlordioxid beim Menschen. Es ist wichtig zu erkennen, dass es in verschiedenen Diskussionen und falschen Darstellungen in den Medien erhebliche Voreingenommenheit gegen Chlordioxidl\u00f6sungen (CDS) gegeben hat, ebenso wie voreingenommene Faktenpr\u00fcfer, die von denjenigen finanziert werden, die von einem falschen Narrativ profitieren.<\/p>


<\/p>\n

Wir bem\u00fchen uns hier um die Darstellung der Wahrheit und heben begutachtete Studien hervor, die sich speziell mit den Auswirkungen auf den Menschen und den damit verbundenen gesundheitlichen Folgen befassen.<\/p>


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Von Experten begutachtete Ver\u00f6ffentlichungen zu CDS am Menschen und verwandte Themen<\/h4>

Auf dieser Seite finden Sie Links zu Forschungsarbeiten \u00fcber Chlordioxid, die sich direkt auf den Menschen beziehen und keine industriellen Anwendungen oder Wasseraufbereitung betreffen. Diese Sammlung ist nicht vollst\u00e4ndig, enth\u00e4lt aber die wichtigsten wissenschaftlichen Studien \u00fcber Chlordioxid, die bisher durchgef\u00fchrt wurden. Sie liegen im englischen Original vor.<\/p>

Wenn Sie auf den Namen klicken, k\u00f6nnen Sie auf den Original-Link zugreifen und die entsprechende Ver\u00f6ffentlichung finden.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\u00a0<\/h3>

1. Internationaler Konsensbericht \u00fcber SARS-Cov-2, COVID-19 und das Immunsystem: eine orthomolekulare Sichtweise
Internationale Gesellschaft f\u00fcr Orthomolekulare Medizin
ISSN:0834-4825 2.<\/p>

https:\/\/isom.ca\/article\/an-international-consensus-report-on-sars-cov-2-covid-19-and-the-immune-system-an-orthomolecular-view\/<\/a><\/p>

2. Chlordioxid in COVID-19: Hypothese zum m\u00f6glichen molekularen Wirkmechanismus bei SARS-CoV-2
Molekulare Medizin und Genetik
ISSN: 1747-0862
https:\/\/www.hilarispublisher.com\/abstract\/chlorine-dioxide-in-covid19-hypothesis-about-the-possible-mechanism-of-molecular-action-in-sarscov2-52824.html<\/a><\/p>

3. Eine neue Perspektive f\u00fcr die Pr\u00e4vention und Heilung von COVID-19-Patienten: Ermutigung medizinischer Teams, mit geheilten Personen, die mit Chlordioxidl\u00f6sung (CDS) behandelt wurden, Kontakt aufzunehmen
Integrative Medical Sciences Conference
ISSN: 2658-8218
https:\/\/mbmj.org\/index.php\/ijms\/article\/view\/229<\/a><\/p>

4. Bestimmung der Wirksamkeit von Chlordioxid bei der Behandlung von COVID-19
Molekulare Medizin und Genetik
ISSN: 1747-0862
https:\/\/www.hilarispublisher.com\/open-access\/determination-of-the-effectiveness-of-chlorine-dioxide-in-the-treatment-of-covid19-67319.html<\/a><\/p>

5. Chlordioxid als alternative Behandlung von COVID-19
Journal of Infectious Diseases and Therapy.
ISSN: 2332-0877
https:\/\/www.omicsonline.org\/open-access\/chlorine-dioxide-as-an-alternative-treatment-for-covid19.pdf<\/a><\/p>

6. Eine retrospektive Beobachtungsstudie \u00fcber die Wirksamkeit von Chlordioxid zur Prophylaxe von COVID19-\u00e4hnlichen Symptomen bei Angeh\u00f6rigen von COVID19-Patienten
INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS
ISSN: 2643-9875
http:\/\/ijmra.in\/v4i8\/2.php<\/a><\/p>

7. Molekulare Interaktion und Hemmung der Bindung von SARS-CoV-2 an den ACE2-Rezeptor
Nature communications chemistry selections
ISSN :2188-5044
https:\/\/pubmed.ncbi.nlm.nih.gov\/32917884\/<\/a><\/p>

8. COVID19 Langfristige Auswirkungen bei Patienten, die mit Chlordioxid behandelt wurden
International Journal of Multidisciplinary Research and Analysis
ISSN :2643-9875
http:\/\/ijmra.in\/v4i8\/14.php<\/a><\/p>

9. Vergleichende Studie von hochreinem Chlordioxid mit zwei anderen Sp\u00fclmitteln in Bezug auf die Lebensf\u00e4higkeit von Stammzellen des parodontalen Ligaments Springer
ISSN: 2627-8626
https:\/\/link.springer.com\/article\/10.1007\/s00784-020-03618-5<\/a><\/p>

10. Eradikation von MRSA durch Chlordioxid Journal of bacteriology and mycology
ISSN: 2469-2786
https:\/\/medcraveonline.com\/JBMOA\/JBMOA-09-00306.pdf<\/a><\/p>

11. Bewertung der Wirksamkeit und Sicherheit einer Chlordioxidl\u00f6sung
International Conference on Environmental Research and Public Health
ISSN: 1660-4601
https:\/\/www.mdpi.com\/1660-4601\/14\/3\/329\/htm<\/a><\/p>

12. Chlordioxid ist ein gr\u00f6\u00dfenselektives antimikrobielles Mittel
PLOS ONE
ISSN: 1932-6203
https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0079157<\/a><\/p>

13. Inaktivierung von Influenzavirus-H\u00e4magglutinin durch Chlordioxid: Oxidation des konservierten Restes Tryptophan 153 an der Rezeptorbindestelle Journal of General Virology
ISSN: 1465-2099
https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/vir.0.044263-0<\/a><\/p>

14. Kann Chlordioxid die Verbreitung von Coronaviren oder anderen
viralen Infektionen verhindern? Medizinische Hypothesen Akad\u00e9miai Kiad\u00f3
ISSN: 2061-4705
https:\/\/akjournals.com\/view\/journals\/2060\/107\/1\/article-p1.xml<\/a><\/p>

15. Inaktivierung von humanen und simianen Rotaviren durch Chlordioxid
American Society for Microbiology („ASM“)
ISSN: 0196-8254
https:\/\/journals.asm.org\/doi\/10.1128\/aem.56.5.1363-1366.1990<\/a><\/p>

16. Kontrollierte klinische Bewertungen von Chlordioxid, Chlorit und Chlorat beim Menschen
Environmental Health Perspectives (EHP)
ISSN: 1542-6351
https:\/\/ehp.niehs.nih.gov\/doi\/10.1289\/ehp.824657<\/a><\/p>

17. Klinische und mikrobiologische Wirksamkeit von Chlordioxid bei der Behandlung von chronischer atrophischer Candidose: eine offene Studie Int Dent J. 2004\u00a0Jun;54(3):154-8. Mohammad AR, Giannini PJ, Preshaw PM, Alliger H. doi: 10.1111\/j.1875-595x.2004.tb00272.x. PMID: 15218896.
https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0020653920350929?via%3Dihub<\/a><\/p>

18. Protein-Denaturierung durch Chlordioxid: Oxidative Modifikation von Tryptophan- und
Tyrosin-Resten Biochemistry ACS PUB
ISSN: 1044-5099
https:\/\/pubs.acs.org\/doi\/full\/10.1021\/bi061827u<\/a><\/p>

19. Chlordioxid hemmt die Replikation des Virus des porcinen reproduktiven und respiratorischen Syndroms durch Blockierung der viralen Adh\u00e4sion Elsevier
ISSN :0922-3444
https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1567134818305549?via%3Dihub<\/a><\/p>

20. Auswirkungen von Chlordioxid auf die Mundhygiene: eine systematische \u00dcbersichtsarbeit und Meta-Analyse
Aktuelles pharmazeutisches Design
ISSN :1873-4286
https:\/\/www.eurekaselect.com\/article\/106659<\/a><\/p>

21. Kinetik und Mechanismus der Chlordioxid- und Chlorit-Oxidation von Cystein und Glutathion Inorg. Chem. ACS PUB
ISSN: 1044-5099
https:\/\/pubs.acs.org\/doi\/full\/10.1021\/ic0609554<\/a><\/p>

22. Die 40-80 nt Region im 50 -NCR des Genoms ist ein kritisches Ziel f\u00fcr die Inaktivierung des Poliovirus durch Chlordioxid
Journal of Medical Virology
ISSN :1096-9071
https:\/\/pubmed.ncbi.nlm.nih.gov\/6295277\/<\/a><\/p>

Forschung \u00fcber die viruzide Aktivit\u00e4t von Chlordioxid. Experimentelle Daten zu felinem Calicivirus, HAV und Coxsackie B5 Journal of preventive medicine and hygiene ISSN:1121-2233
https:\/\/pubmed.ncbi.nlm.nih.gov\/18274345\/<\/a><\/p>

23. Kinetik und Mechanismus der bakteriellen Desinfektion durch Chlordioxid American Society for Microbiology
ISSN: 0569-7603
https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC546889\/<\/a><\/p>

24. Resistenzstudie zum schweren akuten Atemwegssyndrom-assoziierten Coronavirus
Elsevier
ISSN :0922-3444
https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166093405000649?via%3Dihub<\/a><\/p>

25. Sch\u00fctzende Wirkung von Chlordioxid in niedriger Konzentration Journal of General Virology
ISSN :1465-2099
https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/vir.0.83393-0<\/a><\/p>

26. Kann die Nasensp\u00fclung mit Chlordioxid als eine m\u00f6gliche alternative Therapie bei Infektionskrankheiten der Atemwege in Betracht gezogen werden? Das Beispiel von COVID-19
https:\/\/pubmed.ncbi.nlm.nih.gov\/36504072\/<\/a><\/p>

27. Pr\u00e4vention von Infektionen und Gewebereparatur bei Hautl\u00e4sionen durch Behandlungen
auf der Basis einer Chlordioxidl\u00f6sung: Fallstudie
https:\/\/www.literaturepublishers.org\/assets\/images\/articles\/pNf0Sb_ziYD97_60HZa5_3mc6LU_399176.pdf<\/a><\/p>

28. Die Toxizit\u00e4t des COVID-19-Spike-Proteins ist ein Redox-Switch-Ph\u00e4nomen: Ein neuer therapeutischer Ansatz\u00a0 Doi.org\/10.1016\/j.freeradbiomed.2023.05.034
https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584923005014<\/a><\/p>

29. Chlordioxid und Chlorit zur Behandlung von diabetischen Fu\u00dfgeschw\u00fcren International Journal of Medicine and MedicalSciences
DOI:10.5897\/IJMMS2023.1503
https:\/\/www.semanticscholar.org\/reader\/a29e004fec0292d0bddaa0d616e29a529019a34b<\/a><\/p>

30. Fallbericht: Mitf\u00fchlende Anwendung einer L\u00f6sung auf Chlordioxidbasis bei einem Patienten mit metastasiertem Prostatakrebs Gesundheit, Wissenschaft und Technologie 2024
DOI: https:\/\/doi.org\/10.56294\/saludcyt2024699<\/a><\/p>

31. Eradikation von antibiotikaresistenten E. coli, S. aureus, K. pneumoniae, S. pneumoniae, A.
baumannii und P. aeruginosa mit Chlordioxid in vitro Europ\u00e4ische Gesellschaft f\u00fcr Medizin.
https:\/\/esmed.org\/MRA\/mra\/article\/view\/4218<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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32. Clinical case: Resolution of pathologic fracture of metastatic non-Hodgkin’s lymphoma with compassionate therapy. Manuel Aparicio-Alonso, Ver\u00f3nica Torres-Sol\u00f3rzano.
https:\/\/revista.saludcyt.ar\/ojs\/index.php\/sct\/article\/view\/830<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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34. Klarstellung zur Wissenschaft des CDS: Umgang mit Fehlinformationen und Feststellung von Beweisen f\u00fcr seine medizinische Anwendung.<\/p>

https:\/\/ijmra.in\/v8i3\/54.php<\/a><\/p>

PDF herunterladen: https:\/\/ijmra.in\/v8i3\/Doc\/54.pdf<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tEin internationaler Konsensbericht \u00fcber SARS-Cov-2, COVID-19 und das Immunsystem: Eine orthomolekulare Sichtweise<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Ein internationaler Konsensbericht \u00fcber SARS-Cov-2, COVID-19 und das Immunsystem: Eine orthomolekulare Sichtweise<\/strong><\/a><\/p>

International Society for Orthomolecular Medicine\u00a0<\/strong><\/p>

ISSN:0834-4825<\/p>

Author(s):\u00a0Michael J Gonzalez<\/a>1,3\u201a4;\u00a0Jorge R Miranda-Massari<\/a>2\u201a4;\u00a0Peter A McCullough<\/a>5;\u00a0Paul E Marik<\/a>6; Pierre Kory7; Ryan Cole8; Geert Vanden Bossche9; Charles Simone10; Manuel Aparicio Alonso11; Ernesto Prieto Gratacos12;\u00a0Atsuo Yanagisawa<\/a>13;\u00a0Richard Cheng<\/a>14; Eduardo Insignares-Carrione15; Zhiyong Peng\u00b96; Robert J Rowen\u00b97; Teresa B Su\u00b97;\u00a0Frank Shallenberger<\/a>18; David Brownstein19;\u00a0Thomas Levy<\/a>20; Jorge L Cubrias21; Arturo O\u2019Byrne Navia22; Arturo O\u2019Byrne De Valdenebro23;\u00a0Alex Vasquez<\/a>24;\u00a0Ron Hunninghake<\/a>25;\u00a0Andrew Saul<\/a>26; Hugo Galindo27; Andreas L. Kalcker28; Mayca Gonzalez29; Luis A Bonilla-Soto30; Mar\u00eda\u00a0 Carrascal31; Jos\u00e9 W Rodriguez Zayas32;\u00a0Efrain Olszewer<\/a>33;\u00a0 Micha\u00ebl Friedman34; Miguel J Berdiel35; Norman O Gonzalez36; Jose Olalde37; Ines Alfaro38;\u00a0 Roberto Ortiz39; Angie Perez40; Carlos H. Orozco Araya41; Luis Martinez42; Rosalina Valcarcel43; Sylvia Nu\u00f1ez Fidalgo44; Fernando Pinto Floril45; Raul Morales Borges46; Jos\u00e9 R Rodriguez-Gomez47; Jos\u00e9 A Rodriguez-Robles48; Ramphis Diaz49; Carlos M Ricart50<\/p>

  1. University of Puerto Rico, Medical Sciences Campus, School of Public Health, San Juan PR.<\/li>
  2. University of Puerto Rico, Medical Sciences Campus, School of Pharmacy, San Juan PR.<\/li>
  3. Universidad Central del Caribe, School of Chiropractic, Bayamon, PR.<\/li>
  4. EDP University, Naturopathic Sciences Program, Hato Rey, PR.<\/li>
  5. Truth for Health Foundation, Tucson, AZ.<\/li>
  6. Front Line COVID-19 Critical Care Alliance (FLCCC) and Eastern Virginia Medical School, Department of Internal Medicine, VA.<\/li>
  7. Front Line COVID-19 Critical Care Alliance, Madison, WI.<\/li>
  8. Cole Diagnostics, Garden City, ID.<\/li>
  9. Independent virologist and vaccine expert, Cologne, Belgium.<\/li>
  10. \u00a0Simone Protective Cancer Center, Lawrenceville, NJ.<\/li>
  11. Centro M\u00e9dico Jurica, Quer\u00e9taro, M\u00e9xico.<\/li>
  12. Precision Metabolic Oncology 12, Cambridge Science Park, Cambridge, England.<\/li>
  13. Japanese College of Intravenous Therapy, Tokyo, Japan; Japanese Society for Orthomolecular Medicine, Tokyo Japan: International Society for Orthomolecular Medicine, Toronto, Canada.<\/li>
  14. Cheng Integrative Health Center, Doctor\u2019s Weight Loss Center, Columbia, SC.<\/li>
  15. Liechtensteiner Verein fu\u0308r Wissenschaft und Gesundheit, Liechtenstein, Switzerland.<\/li>
  16. Zhognnan Hospital, Wuhan University, Wuhan, Hubei, China.<\/li>
  17. Private Medical Practice, Santa Rosa, CA.<\/li>
  18. Private Medical Practice, Carson City, NV.<\/li>
  19. The Center for Holistic Medicine in West Bloomfield, MI.<\/li>
  20. Riordan Clinic, Wichita, KS.<\/li>
  21. Clinica Cellmedik, Santa Cruz de Tenerife, Spain.<\/li>
  22. Private practice, Bogota, Colombia.<\/li>
  23. Private practice in Clinical Immunology, Buenos Aires, Argentina.<\/li>
  24. International College of Human Nutrition and Functional Medicine, Barcelona, Spain.<\/li>
  25. Riordan Clinic, Wichita, KS.<\/li>
  26. Doctor Yourself.com, Rochester, NY.<\/li>
  27. Country Medical Center, Bogota, Colombia.<\/li>
  28. Independent Research in Biophysics, Berna, Switzerland.<\/li>
  29. Cl\u00ednica Centro, Granada, Spain.<\/li>
  30. University of Puerto Rico, Medical Sciences Campus, School of Public Health, Department of Environmental Health, San Juan, PR.<\/li>
  31. Carrascal Clinic, R\u00edo Piedras, PR.<\/li>
  32. Cardiopulmonary Research Center, Guaynabo, PR;<\/li>
  33. Fundacao de apoio e pesquisa na area de saude-foundation for research in health and medicine Sao Paulo, Brasil.<\/li>
  34. Association for the Advancement of Restorative Medicine (AARM), Montpelier, VT.<\/li>
  35. Berdiel Clinic, Ponce PR.<\/li>
  36. Private Naturopathic Practice, Masters in Naturopathy Program, EDP University of Puerto Rico. San Juan, PR.<\/li>
  37. Centro Medico Regenerativo (CMR), Bayam\u00f3n and Caguas PR.<\/li>
  38. Alpha Institute, Caguas, PR.<\/li>
  39. Holistic University, Department of Nutrition, Mexico City, Mexico.<\/li>
  40. ICEMI Medical Center, San Jose, Costa Rica, CA.<\/li>
  41. Private Medical Practice, San Jose, Costa Rica, CA.<\/li>
  42. Xanogene Clinic, San Juan, PR.<\/li>
  43. Private Medical Practice, San Juan, PR.<\/li>
  44. San Juan City Hospital, ER Dept., San Juan, PR.<\/li>
  45. Private Medical Practice, Quito, Ecuador.<\/li>
  46. Integrative Optimal Health of Puerto Rico, MB & R\u2019s Enterprise, Ashford Institute of Hematology & Oncology, San Juan, PR.<\/li>
  47. Universidad Carlos Albizu, San Juan, PR.<\/li>
  48. Private Medical Practice, San Juan, PR, and Miami, FL.<\/li>
  49. Private Naturopathic Practice, San Juan, PR.<\/li>
  50. University of Puerto Rico Cayey Campus, Dept Biology, Cayey, PR.<\/li><\/ol>

    Abstract<\/strong><\/p>

    An unprecedented worldwide situation has taken place due to the pandemic related to the SARS- CoV-2 virus. In addition to a novel infectious disease and an unparalleled global response, COVID-19 also initiated an unparalleled course of action of vaccine research, production, testing, and distribution. The sense of urgency around combating the viral pandemic has led to public health decisions based on incomplete and non-evidence-based information. Many issues in relation to the virus SARS-Cov-2, the disease COVID-19, and the immune system need to be addressed, clarified, and put in a proper perspective in order to bring this pandemic to a more objective assessment. This analysis may help manage its many challenges more efficiently, in addition, to providing a true opportunity to reduce complications, deaths, and iatrogenic side effects of either the infection or the vaccination, or both. The present consensus report has taken this necessary task to provide a common ground to effectively manage this global situation.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tChlordioxid in COVID-19: Hypothese \u00fcber den m\u00f6glichen Mechanismus der molekularen Wirkung bei SARS-CoV-2<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Chlordioxid in COVID-19: Hypothese \u00fcber den m\u00f6glichen Mechanismus der molekularen Wirkung bei SARS-CoV-2<\/strong><\/a><\/p>

    Molecular and Genetic Medicine ISSN: 1747-0862<\/strong><\/p>

    Eduardo Insignares-Carrione<\/a>*,\u00a0Blanca Bolano G\u00f3mez<\/a>\u00a0and\u00a0Andreas Ludwig Kalcker<\/a><\/p>

    ISSN: 1747-0862<\/a><\/strong><\/p>

    Download PDF<\/strong><\/a><\/p>

    Introduction<\/p>

    COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. It was first detected in the Chinese city of Wuhan (Hubei province) in December 2019. In three months it spread to basically all countries in the world, which is why the World Health Organization declared it a pandemic. (WHO, March 11, 2020).<\/p>

    There is no specific treatment; the main therapeutic measures are to relieve symptoms and maintain vital functions. Research to find an effective treatment began since the pandemic scale of the disease was verified. The central problem is that, eleven months after its official onset, an effective treatment for the disease is still unknown. In the absence of an effective treatment, we studied new therapeutic possibilities with the intention of finding an effective and safe treatment for COVID-19.<\/p>

    In accordance with the above, this research addresses current results and previous research adding the possible therapeutic action as a virucidal of chlorine dioxide in aqueous solution and without the presence of sodium chlorite using the concepts of translational medicine based on knowledge about the structure of the virus and the mechanism of action of chlorine dioxide in viruses, to propose a possible treatment of choice for COVID-19 [1<\/a>,2<\/a>].<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tEine neue Perspektive f\u00fcr die Pr\u00e4vention und Heilung von COVID-19-Patienten: Ermutigung medizinischer Teams zum Kontakt mit geheilten Menschen, die mit Chlordioxid in L\u00f6sung (CDS) behandelt wurden<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Integrative Journal of Medical Sciences (ISSN: 2658-8218)<\/strong><\/p>

    Enrique A. Mart\u00ednezUniversidad Cat\u00f3lica del Norte, Coquimbo, Chile<\/p>

    https:\/\/doi.org\/10.15342\/ijms.7.229<\/strong><\/a><\/p>

    https:\/\/mbmj.org\/index.php\/ijms\/article\/view\/229\u200b<\/span><\/strong><\/a><\/p>

    ABSTRACT:<\/p>

    This article is written to encourage medical teams from all over the world to contact the COVID-19 patients already treated with Chlorine Dioxide in Solution (CDS), a water soluble gas. To contact also their medical teams accompanying the study cases in order to verify the actual health conditions of patients. Finally, the invitation is to question whether CDS should be tried in their respective local healthcare environments, as it is of low cost, it seems highly effective against all viral infections and it has almost no secondary effects.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tChlordioxid als alternative Behandlung f\u00fcr COVID-19<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Chlorine Dioxide as an Alternative Treatment for COVID-19<\/strong><\/a><\/p>

    Journal of infectious disease and therapy.<\/strong><\/p>

    Manuel Aparicio-Alonso<\/a>,\u00a0C. Dom\u00ednguez-S\u00e1nchez<\/a>,\u00a0Marina Banuet-Martinez<\/a><\/p>

    ISSN: 2332-0877<\/a><\/p>

    Download PDF<\/a><\/strong><\/p>

    ABSTRACT:<\/strong><\/p>

    To date, there is no effective prophylactic agent to prevent COVID-19. However, the development of symptoms similar to covid19 could be prevented with an aqueous solution of chlorine dioxide (ClO\u2082). This retrospective study evaluated the effectiveness of an aqueous solution of ClO\u2082 (CDS) as a prophylactic agent in 1,163 family members living with positive\/suspected COVID19 patients. Prophylactic treatment consisted of 0.0003% chlorine dioxide solution (CDS) orally for at least fourteen days. Family members in whom no reports of the development of covid19-like symptoms were found in the medical history were considered successful cases. The efficacy of CDS in preventing covid19-like symptoms was 90.4% (1,051 of 1,163 relatives did not report any symptoms). The comorbidities, sex and severity of the illness of the sick patient did not contribute to the development of symptoms similar to covid19 (P = 0.092, P = 0.351 and P = 0.574, respectively). However, older relatives were more likely to develop covid19-like symptoms (ORa = 4.22, P = 0.002). There was no evidence of alterations in blood parameters or in the QTc interval in relatives who consumed CDS. The recent findings regarding Chlorine Dioxide justify designing clinical trials to assess its efficacy for preventing SARS-CoV-2 infection.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tMolekulare Interaktion und Hemmung der Bindung von SARS-CoV-2 an den ACE2-Rezeptor<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Molekulare Interaktion und Hemmung der Bindung von SARS-CoV-2 an den ACE2-Rezeptor<\/a><\/strong><\/p>

    Nature\u00a0communications<\/strong>\u00a0chemistry selections (ISSN :2188-5044)<\/p>

    Jinsung Yang, Simon J. L. Petitjean, Melanie Koehler, Qingrong Zhang, Andra C. Dumitru, Wenzhang Chen, Sylvie Derclaye, St\u00e9phane P. Vincent, Patrice Soumillion & David Alsteens<\/p>

    Abstract<\/p>

    Study of\u00a0the interactions established between the viral glycoproteins and their host receptors is of critical importance for a better understanding\u00a0of\u00a0virus entry into cells. The novel coronavirus SARS-CoV-2 entry into host cells is mediated by its spike glycoprotein (S-glycoprotein), and the angiotensin-converting enzyme 2 (ACE2) has been identified as a cellular receptor. Here, we use atomic force microscopy to investigate the mechanisms by which the S-glycoprotein binds to the ACE2 receptor. We demonstrate, both on model surfaces and on living cells, that the receptor binding domain (RBD) serves as the binding interface within the S-glycoprotein with the ACE2 receptor and extract the kinetic and thermodynamic properties of this binding pocket. Altogether, these results provide a picture of the established interaction on living cells. Finally, we test several binding inhibitor peptides targeting the virus early attachment stages, offering new perspectives in the treatment of the SARS-CoV-2 infection.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tCOVID19 Langzeitwirkungen bei Patienten, die mit Chlordioxid behandelt werden I<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    International journal of multidisciplinary research and analysis<\/a><\/strong><\/p>

    1Manuel Aparicio-Alonso,<\/span><\/span>2\u00a0Carlos A. Dom\u00ednguez-S\u00e1nchez,\u00a0<\/span><\/span>3<\/span>Marina Banuet-Mart\u00ednez<\/span><\/span><\/p>

    (ISSN :2643-9875)<\/a>\u00a0https:\/\/doi.org\/10.47191\/ijmra\/v4-i8-14<\/a><\/p>

    ABSTRACT:<\/strong><\/p>

    The coronavirus disease 2019 (COVID19) has generated widespread healthcare concerns and has overburdened healthcare institutions. As the number of COVID19 patients recovers, so does the frequency of reports of COVID19-like symptoms following discharge. A telephone survey with standardized questions was undertaken in which participants were asked if they had had any of 25 possible sequelae after being diagnosed with COVID19 and treated with a Chlorine Dioxide Solution (CDS). One hundred sixty-one people completed the survey. We discovered that rising age is a risk factor (OR = 1.035, p = 0.028, 95% CI = 1.004-1.069), and the odds of having any symptoms in moderate patients is 0.077 compared to mild patients (P = 0.003). It was predicted that 64.6 percent of patients treated with CDS for SARS-CoV-2 infection experienced an average of 3.41 long-term effects. There were no variations in the number of sequelae reported by sex, age, COVID19 severity, or therapy method. The five most prevalent manifestations of the 25 distinct long-term symptoms observed in this study were fatigue, hair loss, dyspnea, concentration problem, and sleep difficulties. In addition, individuals treated with multiple drugs (COVID19 conventional treatment plus a CDS) had 2.7 fewer cases of sequelae, and patients treated exclusively with CDS had 6.14 fewer incidences of long-term effects. People who get a CDS are 19% less likely to experience long-term health effects than patients who receive standard COVID19 therapy. According to the findings of this study, patients who receive a CDS have a reduced probability of developing sequelae. Furthermore, the incidence of long-term effects is lower in individuals treated exclusively with a CDS. The recent findings involving Chlorine Dioxide support the development of clinical studies to evaluate its efficacy in preventing the development of COVID19 long-term effects.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tEine retrospektive Beobachtungsstudie zur Wirksamkeit von Chlordioxid zur Prophylaxe von Covid19-\u00e4hnlichen Symptomen bei Angeh\u00f6rigen von COVID19-Patienten<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Eine retrospektive Beobachtungsstudie zur Wirksamkeit von Chlordioxid zur Prophylaxe von Covid19-\u00e4hnlichen Symptomen bei Angeh\u00f6rigen von COVID19-Patienten<\/a><\/strong><\/p>

    INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS<\/strong><\/p>

    1Manuel Aparicio-Alonso, 2Carlos A. Dom\u00ednguez-S\u00e1nchez, 3Marina Banuet-Mart\u00ednez<\/p>

    ISSN: 2643-9875<\/a><\/strong><\/p>

    ABSTRACT:<\/strong><\/p>

    To date, there is no effective prophylactic agent to prevent COVID-19. However, the development of symptoms similar to covid19 could be prevented with an aqueous solution of chlorine dioxide (ClO\u2082). This retrospective study evaluated the effectiveness of an aqueous solution of ClO\u2082 (CDS) as a prophylactic agent in 1,163 family members living with positive\/suspected COVID19 patients. Prophylactic treatment consisted of 0.0003% chlorine dioxide solution (CDS) orally for at least fourteen days. Family members in whom no reports of the development of covid19-like symptoms were found in the medical history were considered successful cases. The efficacy of CDS in preventing covid19-like symptoms was 90.4% (1,051 of 1,163 relatives did not report any symptoms). The comorbidities, sex and severity of the illness of the sick patient did not contribute to the development of symptoms similar to covid19 (P = 0.092, P = 0.351 and P = 0.574, respectively). However, older relatives were more likely to develop covid19-like symptoms (ORa = 4.22, P = 0.002). There was no evidence of alterations in blood parameters or in the QTc interval in relatives who consumed CDS. The recent findings regarding Chlorine Dioxide justify designing clinical trials to assess its efficacy for preventing SARS-CoV-2 infection.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tVergleichende Studie von hochreinem Chlordioxid mit zwei anderen Sp\u00fclmitteln hinsichtlich der Lebensf\u00e4higkeit von Stammzellen des parodontalen Ligaments<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Vergleichende Studie von hochreinem Chlordioxid mit zwei anderen Sp\u00fclmitteln hinsichtlich der Lebensf\u00e4higkeit von Stammzellen des parodontalen Ligaments<\/strong><\/p>

    Orsolya L\u00e1ng, Krisztina S. Nagy, Julia L\u00e1ng, Katalin Perczel-Kov\u00e1ch, Anna Herczegh, Zsolt Lohinai, G\u00e1bor Varga & L\u00e1szl\u00f3 K\u0151hidai<\/p>

    Springer<\/strong>\u00a0(ISSN: 2627-8626)<\/p>

    Abstract<\/p>

    Objectives: Periodontal ligament stem cells (PDLSCs) have an underlined significance as their high proliferative capacity and multipotent differentiation provide an important therapeutic potential. The integrity of these cells is frequently disturbed by the routinely used irrigative compounds applied as periodontal or endodontic disinfectants (e.g., hydrogen peroxide (H\u2082O\u2082) and chlorhexidine (CHX)). Our objectives were (i) to monitor the cytotoxic effect of a novel dental irrigative compound, chlorine dioxide (ClO\u2082), compared to two traditional agents (H\u2082O\u2082, CHX) on PDLSCs and (ii) to test whether the aging factor of PDLSC cultures determines cellular responsiveness to the chemicals tested.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tKontrollierte klinische Evaluierungen von Chlordioxid, Chlorit und Chlorat beim Menschen<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Kontrollierte klinische Evaluierungen von Chlordioxid, Chlorit und Chlorat beim Menschen<\/a><\/strong><\/p>

    Environmental Health Perspectives (EHP)<\/strong><\/p>

    J R Lubbers<\/a>,\u00a0S Chauan<\/a>, and\u00a0J R Bianchine<\/a><\/p>

    (ISSN: 1542-6351)<\/strong><\/a><\/p>

    Abstract<\/p>

    To assess the relative safety of chronically administered chlorine water disinfectants in man, a controlled study was undertaken. The clinical evaluation was conducted in the three phases common to investigational drug studies. Phase I, a rising dose tolerance investigation, examined the acute effects of progressively increasing single doses of chlorine disinfectants to normal healthy adult male volunteers. Phase II considered the impact on normal subjects of daily ingestion of the disinfectants at a concentration of 5 mg\/l. for twelve consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase may be expected to be especially susceptible to oxidative stress; therefore, in Phase III, chlorite at a concentration of 5 mg\/l. was administered daily for twelve consecutive weeks to a small group of potentially at-risk glucose-6-phosphate dehydrogenase-deficient subjects. Physiological impact was assessed by evaluation of a battery of qualitative and quantitative tests. The three phases of this controlled double-blind clinical evaluation of chlorine dioxide and its potential metabolites in human male volunteer subjects were completed uneventfully. There were no obvious undesirable clinical sequellae noted by any of the participating subjects or by the observing medical team. In several cases, statistically significant trends in certain biochemical or physiological parameters were associated with treatment; however, none of these trends was judged to have physiological consequence. One cannot rule out the possibility that, over a longer treatment period, these trends might indeed achieve proportions of clinical importance. However, by the absence of detrimental physiological responses within the limits of the study, the relative safety of oral ingestion of chlorine dioxide and its metabolites, chlorite and chlorate, was demonstrated.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tDenaturierung von Proteinen durch Chlordioxid: Oxidative Modifikation von Tryptophan- und Tyrosinresten<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Denaturierung von Proteinen durch Chlordioxid: Oxidative Modifikation von Tryptophan- und Tyrosinresten<\/a><\/strong><\/p>

    Biochemistry ACS PUB<\/strong><\/p>

    Norio Ogata<\/p>

    (ISSN :0922-3444).<\/a><\/p>

    Abstract<\/p>

    <\/p>

    Oxychlorine compounds, such as hypochlorous acid (HOCl) and chlorine dioxide (ClO\u2082), have potent antimicrobial activity. Although the biochemical mechanism of the antimicrobial activity of HOCl has been extensively investigated, little is known about that of ClO\u2082. Using bovine serum albumin and glucose-6-phosphate dehydrogenase of Saccharomyces cerevisiae<\/i> as model proteins, here I demonstrate that the antimicrobial activity of ClO\u2082 is attributable primarily to its protein-denaturing activity. By solubility analysis, circular dichroism spectroscopy, differential scanning calorimetry, and measurement of enzymatic activity, I demonstrate that protein is rapidly denatured by ClO\u2082 with a concomitant decrease in the concentration of ClO\u2082 in the reaction mixture. Circular dichroism spectra of the ClO\u2082-treated proteins show a change in ellipticity at 220 nm, indicating a decrease in \u03b1-helical content. Differential scanning calorimetry shows that transition temperature and endothermic transition enthalpy of heat-induced unfolding decrease in the ClO\u2082-treated protein. The enzymatic activity of glucose-6-phosphate dehydrogenase decreases to 10% within 15 s of treatment with 10 \u03bcM ClO\u2082. Elemental analyses show that oxygen, but not chlorine, atoms are incorporated in the ClO\u2082-treated protein, providing direct evidence that protein is oxidized by ClO\u2082. Furthermore, mass spectrometry and nuclear magnetic resonance spectroscopy show that tryptophan residues become N<\/i>-formylkynurenine and tyrosine residues become 3,4-dihydroxyphenylalanine (DOPA) or 2,4,5-trihydroxyphenylalanine (TOPA) in the ClO\u2082-treated proteins. Taking these results together, I conclude that microbes are inactivated by ClO\u2082 owing to denaturation of constituent proteins critical to their integrity and\/or function, and that this denaturation is caused primarily by covalent oxidative modification of their tryptophan and tyrosine residues.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tAuswirkungen von Chlordioxid auf die Mundhygiene - eine systematische \u00dcberpr\u00fcfung und Meta-Analyse<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Auswirkungen von Chlordioxid auf die Mundhygiene – eine systematische \u00dcberpr\u00fcfung und Meta-Analyse<\/strong><\/a><\/p>

    Author(s): Be\u00e1ta Ker\u00e9mi, Katalin M\u00e1rta, Korn\u00e9lia Farkas, L\u00e1szl\u00f3 M. Czumbel, Barbara T\u00f3th, Zsolt Szak\u00e1cs, Dezs\u0151 Csupor, J\u00f3zsef Czimmer, Zolt\u00e1n Rumbus, P\u00e9ter R\u00e9v\u00e9sz, Adrienn N\u00e9meth, G\u00e1bor Gerber, P\u00e9ter Hegyi and G\u00e1bor Varga*<\/p>

    DOI:<\/strong>\u00a010.2174\/1381612826666200515134450<\/a><\/p>

    Abstract<\/p>

    Background: Effective and selective oral rinses are required in the daily medical and dental practice. Currently mouthwashes used have substantial side effects.<\/p>

    Objectives: Our aim was to evaluate the efficacy of chlorine dioxide-containing mouthwashes in comparison with other previously established mouth rinses in healthy adults using oral hygiene indices.<\/p>

    Methods: This work was registered in PROSPERO (CRD42018099059) and carried out using multiple databases and reported according to the PRISMA statement. The search terms used were \u201cchlorine dioxide\u201d AND \u201coral\u201d, and only randomised controlled trials (RCTs) were included. The primary outcome was the alteration of the plaque index (PI), while the secondary outcomes were the gingival index (GI) and bacterial counts. For the risk of bias assessment, the Cochrane Risk of Bias Tool was used. Statistical analysis for data heterogeneity was performed by Q-value and I2-tests.<\/p>

    Results: 364 articles were found in the databases. After the selection process, only five RCTs were eligible for meta-analysis. Data heterogeneity was low. There were no statistical differences in effectiveness between chlorine dioxide and other effective mouth rinses in PI (0.720\u00b10.119 vs 0.745\u00b10.131; 95%; confidence intervals (CIs): 0.487-0.952 vs 0.489-1.001, respectively) and GI (0.712\u00b10.130 vs 0.745\u00b10.131; 95% CIs: 0.457\u20130.967 vs 0.489\u2013 1.001, respectively) and also in bacterial counts.<\/p>

    Conclusion: Chlorine dioxide reduces both plaque and gingival indices and bacterial counts in the oral cavity similar to other routinely used oral rinses, however, the evidence supporting this outcome is very limited. Therefore, further large scale RCTs are needed to decrease the risk of bias.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tKinetik und Mechanismen der Chlordioxid- und Chlorit-Oxidation von Cystein und Glutathion<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Kinetik und Mechanismen der Chlordioxid- und Chlorit-Oxidation von Cystein und Glutathion<\/a><\/strong><\/p>

    Inorg. Chem. ACS PUB<\/strong><\/p>

    Ana Ison, Ihab N. Odeh, and Dale W. Margerum<\/p>

    (ISSN: 1044-5099)<\/a><\/p>

    Abstract<\/p>

    <\/p>

    Chlorine dioxide oxidation of cysteine (CSH) is investigated under pseudo-first-order conditions (with excess CSH) in buffered aqueous solutions, p[H+] 2.7\u22129.5 at 25.0 \u00b0C. The rates of chlorine dioxide decay are first order in both ClO\u2082 and CSH concentrations and increase rapidly as the pH increases. The proposed mechanism is an electron transfer from CS- to ClO\u2082 (1.03 \u00d7 108 M-1 s-1) with a subsequent rapid reaction of the CS\u2022<\/b> radical and a second ClO\u2082 to form a cysteinyl\u2212ClO\u2082 adduct (CSOClO). This highly reactive adduct decays via two pathways. In acidic solutions, it hydrolyzes to give CSO\u2082H (sulfinic acid) and HOCl, which in turn rapidly react to form CSO\u2083H (cysteic acid) and Cl-. As the pH increases, the (CSOClO) adduct reacts with CS- by a second pathway to form cystine (CSSC) and chlorite ion (ClO\u2082 -). The reaction stoichiometry changes from 6 ClO2:5 CSH at low pH to 2 ClO2:10 CSH at high pH. The ClO\u2082 oxidation of glutathione anion (GS-) is also rapid with a second-order rate constant of 1.40 \u00d7 108 M-1 s-1. The reaction of ClO\u2082 with CSSC is 7 orders of magnitude slower than the corresponding reaction with cysteinyl anion (CS-) at pH 6.7. Chlorite ion reacts with CSH; however, at p[H+] 6.7, the observed rate of this reaction is slower than the ClO\u2082 \/CSH reaction by 6 orders of magnitude. Chlorite ion oxidizes CSH while being reduced to HOCl, which in turn reacts rapidly with CSH to form Cl-. The reaction products are CSSC and CSO\u2083H with a pH-dependent distribution similar to the ClO\u2082 \/CSH system.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tDie 40-80 nt Region im 50 -NCR des Genoms ist ein kritisches Ziel f\u00fcr die Inaktivierung des Poliovirus durch Chlordioxid<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Die 40-80 nt Region im 50 -NCR des Genoms ist ein kritisches Ziel f\u00fcr die Inaktivierung des Poliovirus durch Chlordioxid<\/a><\/strong><\/p>

    M E Alvarez, R T O’Brien<\/p>

    Journal of Medical Virology<\/p>

    (ISSN :1096-9071)<\/a><\/p>

    Abstract<\/p>

    Chlorine dioxide and iodine inactivated poliovirus more efficiently at pH 10.0 than at pH 6.0. Sedimentation analyses of viruses inactivated by chlorine dioxide and iodine at pH 10.9 showed that viral RNA separated from the capsids, resulting in the conversion of virions from 156S structures to 80S particles. The RNAs release from both chlorine dioxide- and iodine-inactivated viruses cosedimented with intact 35S viral RNA. Both chlorine dioxide and iodine reacted with the capsid proteins of poliovirus and changed the pI from pH 7.0 to pH 5.8. However, the mechanisms of inactivation of poliovirus by chlorine dioxide and iodine were found to differ. Iodine inactivated viruses by impairing their ability to adsorb to HeLa cells, whereas chlorine dioxide-inactivated viruses showed a reduced incorporation of [14C]uridine into new viral RNA. We concluded, then, that chlorine dioxide inactivated poliovirus by reacting with the viral RNA and impairing the ability of the viral genome to act as a template for RNA synthesis.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tKinetik und Mechanismus der bakteriellen Desinfektion durch Chlordioxid<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Kinetik und Mechanismus der bakteriellen Desinfektion durch Chlordioxid<\/a><\/strong><\/p>

    American Society for Microbiology<\/strong><\/p>

    Melvin A. Benarde, W. Brewster Snow, Vincent P. Olivieri, Burton Davidson<\/p>

    (ISSN: 0569-7603)<\/a><\/p>

    Download PDF<\/a><\/strong><\/p>

    Abstract<\/p>

    Survival data are presented for a fecal strain of\u00a0Escherichia coli<\/i>\u00a0exposed to three concentrations of chlorine dioxide at four temperatures. Chick’s first-order reaction equation is generalized to a pseudo\u00a0n<\/i>th-order model. Nonlinear least squares curve-fitting of the survival data to the\u00a0n<\/i>th order model was performed on an analogue computer. The data were observed to follow fractional order kinetics with respect to survival concentration, with an apparent activation energy of 12,000 cal\/mole. Initial experiments support the thesis that the mechanism of chlorine dioxide kill occurs via disruption of protein synthesis.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tStudie \u00fcber die Resistenz von Coronaviren, die mit dem schweren akuten respiratorischen Syndrom assoziiert sind<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Studie \u00fcber die Resistenz von Coronaviren, die mit dem schweren akuten respiratorischen Syndrom assoziiert sind<\/a><\/strong><\/p>

    Elsevier<\/strong><\/p>

    (ISSN :0922-3444)<\/strong><\/a><\/p>

    Xin-Wei Wang a, Jin-Song Li b, Min Jin a, Bei Zhen b, Qing-Xin Kong a, Nong Song a, Wen-Jun Xiao b, Jing Yin a, Wei Wei b, Gui-Jie Wang b, Bing-yin Si b, Bao-Zhong Guo b, Chao Liu c, Guo-Rong Ou a, Min-Nian Wang b, Tong-Yu Fang d, Fu-Huan Chao a, Jun-Wen Li\u00a0<\/p>

    Abstract<\/p>

    In this study, the persistence of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) was observed in feces, urine and water. In addition, the inactivation of SARS-CoV in wastewater with sodium hypochlorite and chlorine dioxide was also studied. In vitro experiments demonstrated that the virus could only persist for 2 days in hospital wastewater, domestic sewage and dechlorinated tap water, while 3 days in feces, 14 days in PBS and 17 days in urine at 20\u00a0\u00b0C. However, at 4\u00a0\u00b0C, the SARS-CoV could persist for 14 days in wastewater and at least 17 days in feces or urine. SARS-CoV is more susceptible to disinfectants than\u00a0Escherichia coli<\/em>\u00a0and f2\u00a0phage. Free chlorine was found to inactivate SARS-CoV better than chlorine dioxide. Free residue chlorine over 0.5\u00a0mg\/L for chlorine or 2.19\u00a0mg\/L for chlorine dioxide in wastewater ensures complete inactivation of SARS-CoV while it does not inactivate completely\u00a0E. coli<\/em>\u00a0and f2\u00a0phage.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tSch\u00fctzende Wirkung von Chlordioxid in niedriger Konzentration<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Sch\u00fctzende Wirkung von Chlordioxid in niedriger Konzentration<\/strong><\/a><\/p>

    Journal of General Virology<\/strong><\/p>

    Norio Ogata1, Takashi Shibata1<\/p>

    (ISSN :1465-2099)<\/a><\/strong><\/p>

    ABSTRACT<\/a>\u00a0<\/p>

    Influenza virus infection is one of the major causes of human morbidity and mortality. Between humans, this virus spreads mostly via aerosols excreted from the respiratory system. Current means of prevention of influenza virus infection are not entirely satisfactory because of their limited efficacy. Safe and effective preventive measures against pandemic influenza are greatly needed. We demonstrate that infection of mice induced by aerosols of influenza A virus was prevented by chlorine dioxide (ClO\u2082) gas at an extremely low concentration (below the long-term permissible exposure level to humans, namely 0.1\u2005p.p.m.). Mice in semi-closed cages were exposed to aerosols of influenza A virus (1\u2005LD50) and ClO\u2082 gas (0.03\u2005p.p.m.) simultaneously for 15\u2005min. Three days after exposure, pulmonary virus titre (TCID50) was 102.6\u00b11.5 in five mice treated with ClO\u2082, whilst it was 106.7\u00b10.2 in five mice that had not been treated (P=0.003). Cumulative mortality after 16\u2005days was 0\/10 mice treated with ClO\u2082 and 7\/10 mice that had not been treated (P=0.002). In in vitro experiments, ClO\u2082 denatured viral envelope proteins (haemagglutinin and neuraminidase) that are indispensable for infectivity of the virus, and abolished infectivity. Taken together, we conclude that ClO\u2082 gas is effective at preventing aerosol-induced influenza virus infection in mice by denaturing viral envelope proteins at a concentration well below the permissible exposure level to humans. ClO\u2082 gas could therefore be useful as a preventive means against influenza in places of human activity without necessitating evacuation.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tKann die Nasensp\u00fclung mit Chlordioxid als m\u00f6gliche alternative Therapie bei Infektionskrankheiten der Atemwege in Betracht gezogen werden? Das Beispiel von COVID-19<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Kann die Nasensp\u00fclung mit Chlordioxid als m\u00f6gliche alternative Therapie bei Infektionskrankheiten der Atemwege in Betracht gezogen werden? Das Beispiel von COVID-19<\/a><\/strong><\/p>

    BioScience Trends<\/strong><\/p>

    Jing Cao, Yirong Shi, Min Wen, Yuanyuan Peng, Qiqi Miao, Xiaoning Liu, Mingbin Zheng, Tetsuya Asakawa, Hongzhou Lu<\/p>

    \u00a0<\/strong>https:\/\/doi.org\/10.5582\/bst.2022.01495<\/strong><\/a><\/p>

    Abstract<\/p>

    Chlorine dioxide (ClO\u2082) is a high-level disinfectant that is safe and widely used for sterilization. Due to the limitations on preparing a stable solution, direct use of ClO\u2082 in the human body is limited. Nasal irrigation is an alternative therapy used to treat respiratory infectious diseases. This study briefly summarizes the available evidence regarding the safety\/efficacy of directly using ClO\u2082 on the human body as well as the approach of nasal irrigation to treat COVID-19. Based on the available information, as well as a preliminary experiment that comprehensively evaluated the efficacy and safety of ClO\u2082, 25-50 ppm was deemed to be an appropriate concentration of ClO\u2082 for nasal irrigation to treat COVID-19. This finding requires further verification. Nasal irrigation with ClO\u2082 can be considered as a potential alternative therapy to treat respiratory infectious diseases, and COVID-19 in particular.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tInfektionsvorbeugung und Gewebereparatur bei Hautl\u00e4sionen durch Behandlungen auf der Basis einer Chlordioxidl\u00f6sung: Fallstudien<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Infektionsvorbeugung und Gewebereparatur bei Hautl\u00e4sionen durch Behandlungen auf der Basis einer Chlordioxidl\u00f6sung: Fallstudien<\/strong><\/a><\/p>

    Literaturepublishers<\/strong><\/p>

    Aparicio-Alonso M<\/p>

    Abstract\u00a0<\/p>

    Optimal regeneration of skin lesions needs to ensure protection against opportunistic infections that may hinder the healing process or increase the risk of infection. The use of antibiotics to avoid infection can, in some cases, interfere with tissue regeneration, and often fails due to resistant bacterial strains. Thus, there is a need to expand the arsenal of safe and effective treatment options available. Here, we document the prevention of infections and tissue repair in skin lesions using treatments based on a chlorine dioxide solution. We document four case reports, that include an abdominal burn by a chemical agent, a palpebral burn by extreme heat, limb ulceration due to vascular insufficiency, and a melanoma of the scalp. All lesions were treated topically with a chlorine dioxide solution, and systemically when necessary, according to previously proposed protocols. All four patients showed complete dermal regeneration, with aesthetic results, no side effects or any evidence of adverse effects or interactions with the concomitant treatments used. The results constitute evidence that a topical or systemic solution of chlorine dioxide is safe as an antiseptic treatment in the adequate and swift resolution of skin lesions.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tDie Toxizit\u00e4t des Spike-Proteins von COVID-19 ist ein Ph\u00e4nomen der Redox-Verschiebung: Ein neuer therapeutischer Ansatz<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Die Toxizit\u00e4t des Spike-Proteins von COVID-19 ist ein Ph\u00e4nomen der Redox-Verschiebung: Ein neuer therapeutischer Ansatz<\/a><\/strong><\/p>

    Elservier\u200b<\/strong><\/p>

    Laurent Schwartz a, Manuel Aparicio-Alonso b, Marc Henry c, Miroslav Radman d, Romain Attal e, Ashraf Bakkar f<\/p>

    https:\/\/doi.org\/10.1016\/j.freeradbiomed.2023.05.034<\/a><\/p>

    Abstract<\/p>

    We previously demonstrated that most\u00a0diseases<\/a>\u00a0display a form of\u00a0anabolism<\/a>\u00a0due to mitochondrial impairment: in cancer, a daughter cell is formed; in Alzheimer’s disease,\u00a0amyloid plaques<\/a>; in inflammation cytokines and\u00a0lymphokines<\/a>.<\/p>

    The infection by Covid-19 follows a similar pattern. Long-term effects include redox shift and cellular anabolism as a result of the\u00a0Warburg effect<\/a>\u00a0and mitochondrial dysfunction. This unrelenting anabolism leads to the\u00a0cytokine storm<\/a>, chronic fatigue,\u00a0chronic inflammation<\/a>\u00a0or\u00a0neurodegenerative diseases<\/a>.\u00a0Drugs<\/a>\u00a0such as\u00a0Lipoic acid<\/a>\u00a0and\u00a0Methylene Blue<\/a>\u00a0have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism. Similarly, coMeBining Methylene Blue,\u00a0Chlorine dioxide<\/a>\u00a0and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism.<\/p>

    Graphical abstract<\/h6>

    <\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tChlordioxid ist ein wirksameres antivirales Mittel gegen SARS-CoV-2 als Natriumhypochlorit<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Chlordioxid ist ein wirksameres antivirales Mittel gegen SARS-CoV-2 als Natriumhypochlorit<\/a><\/strong><\/p>

    Elservier<\/strong><\/p>

    N. Hatanaka , B. Xu , M. Yasugi , H. Morino , H. Tagishi , T. Miura , T. Shibata , S. Yamasaki<\/p>

    Summary<\/p>

    Background<\/p>

    A new coronavirus (SARS-CoV-2) abruptly emerged in Wuhan, China, in 2019 and rapidly spread globally to cause the COVID-19 pandemic.<\/p>

    Aim<\/p>

    To examine the anti-SARS-CoV-2 activity of the potent disinfectant Cleverin, the major disinfecting component of which is chlorine dioxide (ClO\u2082); and to compare the results with that of sodium hypochlorite in the presence or absence of 0.5% or 1.0% foetal bovine serum (FBS).<\/p>

    Methods<\/p>

    Concentrated SARS-CoV-2 viruses were treated with various concentrations of ClO\u2082 and sodium hypochlorite and 50% tissue culture infective dose was calcurated to evaluate the antiviral activity of each chemical.<\/p>

    Findings<\/p>

    When SARS-CoV-2 viruses were treated with 0.8 ppm ClO\u2082 or sodium hypochlorite, viral titre was decreased only by 1 log10 TCID50\/mL in 3 min. However, the viral titre was decreased by more than 4 log10 TCID50\/mL when treated with 80 ppm of each chemical for 10 s regardless of presence or absence of FBS. It should be emphasized that treatment with 24 ppm of ClO\u2082 inactivated more than 99.99% SARS-CoV-2 within 10 s or 99.99% SARS-CoV-2 in 1 min in the presence of 0.5% or 1.0% FBS, respectively. By contrast, 24 ppm of sodium hypochlorite inactivated only 99% or 90% SARS-CoV-2 in 3 min under similar conditions. Notably, except for ClO\u2082, the other components of Cleverin such as sodium chlorite, decaglycerol monolaurate, and silicone showed no significant antiviral activity.<\/p>

    Conclusion<\/p>

    Altogether, the results strongly suggest that although ClO\u2082 and sodium hypochlorite are strong antiviral agents in absence of organic matter but in presence of organic matter, ClO\u2082 is a more potent antiviral agent against SARS-CoV-2 than sodium hypochlorite.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

    \n\t\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tEradikation von Borrelia burgdoferi in vitro durch Chlordioxid: Ein neuer Ansatz<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

    Autor:<\/strong><\/p>