{"id":1406,"date":"2023-07-17T20:43:53","date_gmt":"2023-07-17T18:43:53","guid":{"rendered":"https:\/\/andreaskalcker.com\/publicaciones-sobre-clo%e2%82%82\/"},"modified":"2024-01-17T16:33:39","modified_gmt":"2024-01-17T15:33:39","slug":"veroeffentlichungen-ueber-clo%e2%82%82","status":"publish","type":"page","link":"https:\/\/andreaskalcker.com\/de\/veroeffentlichungen-ueber-clo%e2%82%82\/","title":{"rendered":"Ver\u00f6ffentlichungen \u00fcber ClO\u2082"},"content":{"rendered":"\t\t
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Ver\u00f6ffentlichungen \u00fcber ClO\u2082<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Auf dieser Seite finden Sie Links zu Forschungsarbeiten \u00fcber Chlordioxid, die weder in direktem Zusammenhang mit dem Menschen stehen noch ausschlie\u00dflich auf industrielle Anwendungen oder die Wasseraufbereitung beschr\u00e4nkt sind. Diese Sammlung ist nicht vollst\u00e4ndig, enth\u00e4lt aber die bisher wichtigsten wissenschaftlichen Studien \u00fcber Chlordioxid.<\/p>

Wenn Sie auf den DOI klicken, k\u00f6nnen Sie auf den urspr\u00fcnglichen Link zugreifen und die entsprechende Ver\u00f6ffentlichung finden.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tEfficacy and Safety Evaluation of a Chlorine Dioxide Solution <\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Jui-Wen Ma 1,2, Bin-Syuan Huang 1\u00a0, Chu-Wei Hsu 1, Chun-Wei Peng 1, Ming-Long Cheng 1,Jung-Yie Kao 2, Tzong-Der Way 2,3,4, Hao-Chang Yin 1,* and Shan-Shue Wang 5,*<\/p>

1 Unique Biotech Co., Ltd., Rm. 1, 22 F, No. 56, Minsheng 1st Road, Xinxing District, Kaohsiung 800, Taiwan;<\/p>

https:\/\/a26154295@gmail.com\/ (J.-W.M.); https:\/\/chiralrecognize@gmail.com\/ (B.-S.H.); https:\/\/wei751001@gmail.com\/ (C.-W.H.);<\/p>

https:\/\/f08220927@gmail.com\/ (C.-W.P.); https:\/\/great.tree00@msa.hinet.net\/ (M.-L.C.)<\/p>

2\u00a0Institute of Biochemistry, College of Life Science, National Chung Hsing University, Received: 24 February 2017; Accepted: 17 March 2017; Published: 22 March 2017<\/p>

DOI:\u00a0<\/strong>10.3390\/ijerph14030329<\/strong><\/a><\/p>

Download PDF<\/a><\/strong><\/p>

Abstract:\u00a0<\/p>

In this study, a chlorine dioxide solution (UC-1) composed of chlorine dioxide was produced using an electrolytic method and subsequently purified using a membrane. UC-1 was determined to contain 2000 ppm of gaseous chlorine dioxide in water. The efficacy and safety of UC-1 were evaluated. The antimicrobial activity was more than 98.2% reduction when UC-1 concentrations were 5 and 20 ppm for bacteria and fungi, respectively. The half maximal inhibitory concentrations (IC50) of H1N1, influenza virus B\/TW\/71718\/04, and EV71 were 84.65 \u00b1 0.64, 95.91 \u00b1 11.61, and 46.39 \u00b1 1.97 ppm, respectively. A 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test revealed that the cell viability of mouse lung fibroblast L929 cells was 93.7% at a 200 ppm UC-1 concentration that is higher than that anticipated in routine use. Moreover, 50 ppm UC-1 showed no significant symptoms in a rabbit ocular irritation test. In an inhalation toxicity test, treatment with 20 ppm UC-1 for 24 hours showed no abnormality and no mortality in clinical symptoms and normal functioning of the lung and other organs. A ClO2 concentration of up to 40 ppm in drinking water did not show any toxicity in a subchronic oral toxicity test. Herein, UC-1 showed favorable disinfection activity and a higher safety profile tendency than in previous reports.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tChlorine dioxide is a size selective antimicrobial agent<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Zolt\u00e1n Noszticzius, Maria Wittmann*, Krist\u00f3f K\u00e1ly-Kullai, Zolt\u00e1n Beregv\u00e1ri, Istv\u00e1n Kiss, L\u00e1szl\u00f3 Rosivall, J\u00e1nos Szegedi<\/p>

1 Department of Physics, Budapest University of Technology and Economics, Budapest, Hungary 2 J\u00f3sa Andr\u00e1s Hospital, Ny\u00edregyh\u00e1za, Hungary 3 St. Imre Hospital, Budapest, Hungary 4 Semmelweis University, Budapest, Hungary<\/p>

https:\/\/doi.org\/10.1371\/journal.pone.0079157<\/strong><\/a><\/p>

Abstract<\/p>

Background\/Aims: ClO\u2082, the so-called \u201cideal biocide\u201d, could also be applied as an antiseptic if it was understood why the solution killing microbes rapidly does not cause any harm to humans or animals. Our aim was to find the source of that selectivity by studying its reaction-diffusion mechanism both theoretically and experimentally.<\/p>

Methods: ClO\u2082 permeation measurements through protein membranes were performed and the time delay of ClO\u2082 transport due to reaction and diffusion was determined. To calculate ClO\u2082 penetration depths and estimate bacterial killing times, approximate solutions of the reaction-diffusion equation were derived. In these calculations, evaporation rates of ClO\u2082 were also measured and taken into account.<\/p>

Results: The rate law of the reaction-diffusion model predicts that the killing time is proportional to the square of the characteristic size (e.g. diameter) of a body, thus small ones will be killed extremely fast. For example, the killing time for a bacterium is on the order of milliseconds in a 300 ppm ClO\u2082 solution. Thus, a few minutes of contact time (limited by the volatility of ClO\u2082) is quite enough to kill all bacteria, but short enough to keep ClO\u2082 penetration into the living tissues of a greater organism safely below 0.1 mm, minimizing cytotoxic effects when applying it as an antiseptic. Additional properties of ClO\u2082 , advantageous for an antiseptic, are also discussed. Most importantly, bacteria are not able to develop resistance against ClO\u2082 as it reacts with biological thiols which play a vital role in all living organisms.<\/p>

Conclusion: Selectivity of ClO\u2082 between humans and bacteria is based not on their different biochemistry, but on their different size. We hope to initiate clinical applications of this promising local antiseptic.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tMolecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Jinsung Yang1,4, Simon J. L. Petitjean1,4, Melanie Koehler1, Qingrong Zhang1, Andra C. Dumitru1, Wenzhang Chen2, Sylvie Derclaye1, St\u00e9phane P. Vincent2, Patrice Soumillion1 & David Alsteens1,3\u2709<\/p>

DOI:\u00a010.1038\/s41467-020-18319-6<\/strong><\/a><\/p>

Study of the interactions established between the viral glycoproteins and their host receptors is of critical importance for a better understanding of virus entry into cells. The novel coronavirus SARS-CoV-2\u2019s entry into host cells is mediated by its spike glycoprotein (S-glycoprotein), and the angiotensin-converting enzyme 2 (ACE2) has been identified as a cellular receptor. Here, we use atomic force microscopy to investigate the mechanisms by which the S-glycoprotein binds to the ACE2 receptor. We demonstrate, both on model surfaces and on living cells, that the receptor binding domain (RBD) serves as the binding interface within the S-glycoprotein with the ACE2 receptor and extract the kinetic and thermodynamic properties of this binding pocket. Altogether, these results provide a picture of the established interaction on living cells. Finally, we test several binding inhibitor peptides targeting the virus\u2019s early attachment stages, offering new perspectives in the treatment of the SARS-CoV-2 infection.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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Zhenbang Zhu, Yang Guo, Piao Yu, Xiaoying Wang, Xiaoxiao Zhang, Wenjuan Dong,<\/p>

Xiaohong Liu, Chunhe Guo\u204e<\/p>

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, North Third Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong<\/p>

510006, PR China<\/p>

https:\/\/doi.org\/10.1016\/j.meegid.2018.11.002<\/strong><\/a><\/p>

ABSTRACT<\/p>

Porcine reproductive and respiratory syndrome virus (PRRSV) causes a great economic loss to the swine industry globally. Current prevention and treatment measures are not effective in controlling the outbreak and spread of porcine reproductive and respiratory syndrome (PRRS). In other words, new antiviral strategies are urgently needed. Chlorine dioxide (ClO\u2082 ) is regarded as a broad-spectrum disinfectant with strong inhibitory effects on microbes and parasites. The purpose of this study was to evaluate the inhibitory effects and underlying molecular mechanisms of ClO\u2082 against PRRSV infection in vitro. Here, we identified that ClO\u2082 (the purity is 99%) could inhibit the infection and replication of PRRSV in both Marc-145 cells and porcine alveolar macrophages (PAMs). ClO\u2082 could block PRRSV binding to cells rather than internalization and release, suggesting that ClO\u2082 blocks the first stage of the virus life cycle. We also demonstrated that the inhibition exerted by ClO\u2082 was attributed to the degradation of PRRSV genome and proteins. Moreover, we confirmed that ClO\u2082 could decrease the expression of inflammatory cytokines induced by PRRSV. In summary, ClO\u2082 is an efficient agent and potently suppresses PRRSV infection in vitro.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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Volume 9 Issue 3 – 2021<\/p>

George Georgiou<\/p>

Da Vinci BioSciences Research Centre, Cyprus<\/p>

Correspondence: George Georgiou, Director, Da Vinci<\/p>

BioSciences Research Centre Larnaca, Cyprus,<\/p>

Email<\/p>

Received: June 29, 2021 | Published: July 30, 2021<\/p>

\u00a0DOI:\u00a010.15406\/jbmoa.2021.09.00306<\/strong><\/a><\/p>

Abstract<\/p>

Antimicrobial-resistant (AMR) infections currently claim at least 50,000 lives each year across Europe and the US alone, with many hundreds of thousands more dying in other areas of the world. In 15 European countries, more than 10% of bloodstream Staphylococcus aureus infections are caused by methicillin-resistant strains (MRSA), with several of these countries seeing resistance rates closer to 50%. Moreover, while the number of antibiotic-resistant infections is on the rise, the number of new antibiotics is declining. It is therefore imperative that new, novel treatments of AMR are sought, and this is the premise of this research \u2013 using natural substances to eradicate MRSA that do not create further resistance. Chlorine dioxide used in vitro has been our main focus of this research, as it was the most effective compared to other natural substances tested.<\/p>

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Orsolya L\u00e1ng1 & Krisztina S. Nagy2,3 & Julia L\u00e1ng1 & Katalin Perczel-Kov\u00e1ch2,4 & Anna Herczegh5 & Zsolt Lohinai5 &<\/p>

G\u00e1bor Varga2 & L\u00e1szl\u00f3 K\u0151hidai1<\/p>

Received: 16 June 2020 \/Accepted: 1 October 2020<\/p>

https:\/\/doi.org\/10.1007\/s00784-020-03618-5<\/a><\/p>

Abstract<\/p>

Objectives Periodontal ligament stem cells (PDLSCs) have an important significance as their high proliferative capacity and multipotent differentiation provide important therapeutic potential. The integrity of these cells is frequently disturbed by the routinely used irrigative compounds applied as periodontal or endodontic disinfectants (e.g., hydrogen peroxide (H\u2082O\u2082) and chlorhexidine (CHX)). Our objectives were (i) to monitor the cytotoxic effect of a novel dental irrigative compound, chlorine dioxide (ClO\u2082 ), compared to two traditional agents (H\u2082O\u2082, CHX) on PDLSCs and (ii) to test whether the aging factor of PDLSC cultures determines cellular responsiveness to the chemicals tested.<\/p>

Methods Impedimetry (concentration-response study), WST-1 assays (WST = water soluble tetrazolium salt), and morphology analysis were performed to measure changes in cell viability induced by the 3 disinfectants; immunocytochemistry of stem cell markers (STRO-1, CD90, and CD105) measured the induced mesenchymal characteristics.<\/p>

Results Cell viability experiments demonstrated that the application of ClO\u2082 does not lead to a significant decrease in viability of PDLSCs in concentrations used to kill microbes. On the contrary, traditional irrigants, H2O2, and CHX are highly toxic on PDLSCs. Aging of PDLSC cultures (passages 3 vs. 7) has characteristic effects on their responsiveness to these agents as the increased expression of mesenchymal stem cell markers turns to decreased.<\/p>

Conclusions and clinical relevance While the active ingredients of mouthwash (H2O2, CHX) applied in endodontic or periodontitis management have a serious toxic effect on PDLSCs, the novel hyperpure ClO\u2082 is less toxic, providing an environment favoring dental structure regenerations during disinfectant interventions.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tChlorine Dioxide (ClO\u2082) as a Non-Toxic Antimicrobial Agent for Virus, Bacteria and Yeast (Candida Albicans)<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Robert O Young\u00a0<\/i><\/p>

Universal Medical Imaging Group, USA<\/p>

Correspondence:<\/strong>\u00a0Robert O Young, pH Miracle Inc., 16390 Dia del Sol, Valley Center, California, 92082, USA, Tel 760 751 8321<\/p>

Received:\u00a0December 26, 2015 |\u00a0Published:\u00a0October 8, 2016<\/p>

Citation:\u00a0<\/strong>Young RO (2016) Chlorine Dioxide (ClO\u2082 ) As a Non-Toxic Antimicrobial Agent for Virus, Bacteria and Yeast (Candida Albicans). Int J Vaccines Vaccin 2(6):\u00a0<\/p>

DOI:<\/strong>10.15406\/ijvv.2016.02.00052<\/strong><\/a><\/p>

<\/i>\u00a0Download PDF<\/a><\/p>

Abstract<\/h6>

The use of a family of chemical agents, releasing active species of oxygen, effective against infectious microorganisms and viruses is described with emphasis on Chlorine Dioxide (ClO\u2082 ), one of the oxides of chlorine. Also discussed are ozone, hypochlorite, periodate and the known mechanisms of action by which certain white blood cells attach and eradicate infectious microorganisms and primitive bacteria also known as viruses.<\/p>

Explanation of the biochemical mechanisms of acid of ClO\u2082 as an anti-microbial agent, is presented. Particular attention is given to Candida albicans, cytomegalovirus, polio virus, Herpes I and II, HTLV-III and Pseudomonas responding to the clinical application of ClO\u2082 . It is implied that these biochemical mechanisms are so fundamental that the development of resistant strains of bacteria and\/or yeast would not occur with other anti-infectious agents. Limited lists of health abnormalities that respond to ClO\u2082\u00a0 are discussed.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tCan nasal irrigation with chlorine dioxide be considered as a potential alternative therapy for respiratory infectious diseases? The example of COVID-19<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Jing Cao1,\u00a7 Yirong Shi1,\u00a7 Min Wen1,\u00a7 Yuanyuan Peng1 Qiqi Miao1 Xiaoning Liu1<\/p>

Mingbin Zheng2 Tetsuya Asakawa2,* Hongzhou Lu2,3,*<\/p>

1 Department of Nursing, National Clinical Research Center for Infectious Diseases, Third People\u2019s Hospital of Shenzhen, Shenzhen, Guangdong, China 2 Institute of Neurology, National Clinical Research Center for Infectious Diseases, Third People\u2019s Hospital of Shenzhen, Shenzhen, Guangdong, China 3 Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Third People\u2019s Hospital of Shenzhen, Shenzhen, Guangdong, China<\/p>

DOI: 10.5582\/bst.2022.01495<\/a><\/p>

\u00a0Summary Keywords: chlorine dioxide (ClO\u2082 ), nasal irrigation, COVID-19, SARS-CoV-2, respiratory infectious diseases.<\/p>

Chlorine dioxide (ClO\u2082 ) is a high-level disinfectant that is safe and widely used for sterilization. However, due to limitations in preparing a stable solution, direct use of ClO\u2082 in the human body is limited. Nasal irrigation is an alternative therapy used to treat respiratory infectious diseases. This study provides a brief summary of the available evidence regarding the safety and efficacy of using ClO\u2082\u00a0 directly on the human body, as well as the use of nasal irrigation to treat COVID-19. Based on the available information and a preliminary experiment that evaluated the efficacy and safety of ClO\u2082 , a concentration of 25-50 ppm was considered appropriate for nasal irrigation to treat COVID-19. This finding requires further verification. Nasal irrigation with ClO\u2082 can be considered as a potential alternative therapy to treat respiratory infectious diseases, particularly COVID-19.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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George Georgiou,\u00a0<\/p>

2022. Eradication of Borrelia\u00a0<\/p>

Burgdoferi in vitro using Chlorine\u00a0<\/p>

Dioxide: A Novel Approach,\u00a0<\/p>

Medical Research Archives,\u00a0<\/p>

[online] 10(11).\u00a0<\/p>

DOI:<\/strong>\u00a0<\/strong>https:\/\/doi.org\/10.18103\/mra.v10i11.3279<\/strong><\/a><\/p>

ABSTRACT Lyme disease, which is caused by the spirochete Borrelia burgdorferi, is the most prevalent tick-borne illness in the world today and has grown into a major public health problem during the last decade, despite decades of efforts from various health professionals. The conventional treatment for Lyme disease is the use of a variety of antibiotics, but relapse often occurs when antibiotics are discontinued. There are several reasons why this relapse may occur, given that B. burgdorferi is a pleomorphic microorganism that can convert from vegetative spirochetes to a variety of different round bodies and biofilm colonies. Therefore, there is an urgent need for novel approaches that can eliminate all these different morphologies. This has challenged many health practitioners around the world, not to mention the suffering of many afflicted people. In this study, Chlorine dioxide (CD) at different concentrations was tested for its effectiveness in vitro against B. burgdorferi using combined fluorescent and darkfield microscopy with Live-or-Dye staining methods. Our experiments demonstrated that it is possible to completely eradicate all forms of B. burgdorferi at specific concentrations of Chlorine dioxide. Our extensive research has shown that Chlorine dioxide can be used for the eradication of B. burgdorferi morphologies. At certain concentrations of chlorine dioxide above 2 ppm, the Borrelia morphologies appear to be eradicated as there is no motility of either spirochetes or round bodies, only biofilms visible. However, incubating again for another 7 days resulted in the Borrelia being motile again as they come out of the biofilms. We, therefore, decided to conduct each experiment with what we termed the Regrowth Kill Test (RKT) by incubating the initial sample with the CD in an incubator at 37 degrees Celsius in the Campypack for 7 days. It appeared that the biofilms that are quickly formed as soon as the CD is added in the initial experiment broke up and released small spirochetes and round bodies of different morphologies. After numerous RKT experiments, it was determined that the concentration that resulted in a near-complete disinfection of the spirochetes as well as round bodies was 30 ppm CD.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tA New Perspective for Prevention and to Cure COVID-19 Patients: Encouraging Medical Teams to Contact Healed People Treated with Chlorine Dioxide in Solution (CDS)<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Enrique A. Mart\u00ednez<\/p>

Universidad Cat\u00f3lica del Norte, Coquimbo, Chile<\/p>

https:\/\/doi.org\/10.15342\/ijms.7.229<\/strong><\/a><\/p>

ABSTRACT<\/p>

This article is written to encourage medical teams from all over the world to contact the COVID-19 patients already treated with Chlorine Dioxide in Solution (CDS), a water-soluble gas. To also contact their medical teams accompanying the study cases in order to verify the actual health conditions of patients. Finally, the invitation is to question whether CDS should be tried in their respective local healthcare environments, as it is of low cost, it seems highly effective against all viral infections, and it has almost no secondary effects.<\/p>

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Jaiprakash G. Shewale1 | H. Carl Gelhaus2 | James L. Ratcliff1 | Yvonne L. Hernandez-Kapila3 1 Rowpar Pharmaceuticals, Inc., Scottsdale, Arizona, USA 2 MRIGlobal, Kansas City, Missouri, USA 3 Division of Periodontology, Department of Orofacial Sciences, University of California, San Francisco, San Francisco, California, USA<\/p>

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\u00a0DOI: 10.1111\/odi.14044<\/strong><\/a><\/p>

Abstract\u00a0<\/p>

Objective: To determine the in vitro antiviral activity of oral care products containing stabilized chlorine dioxide toward infectious viruses that harbor in the oral cavity. Specifically, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), SARSCoV, human coronavirus (HCoV) 229E, influenza A (H3N2), rhinovirus type 14, adenovirus type 5, and herpes simplex virus (HSV) type 1 and 2 were examined. Methods: Validated in vitro suspension virucidal assays were used. The test product was mixed with the test virus for 30, 60, or 120 s, neutralized with sodium thiosulfate, serially diluted in dilution medium in a 96-well plate, and incubated in a carbon dioxide incubator for 7 days. The 50% Tissue Culture Infectious Dose per milliliter was determined. Results: Two rinses, one oral spray, and one fluoride toothpaste showed log reduction of severe acute respiratory syndrome coronavirus-2 ranging from 1.81 to 2.98 and of influenza A from 2.58 to 4.13, respectively, within 30 s of contact time; similar results were obtained at 60 s. Further, the Ultra Sensitive rinse showed 0.19, 0.75, 1.58, 1.75, 2.66, and 3.24 log reduction of severe acute respiratory syndrome coronavirus, human coronavirus 229E, rhinovirus type 14, adenovirus type 5, and herpes simplex virus type 1 and type 2, respectively, within 30 s of contact time. Conclusion: Stabilized chlorine dioxide containing Cl\u014dSYS\u00ae oral care products reduced the viral load of multiple viruses within 30 s. The results warrant further investigation for potential in vivo applications.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tNebulized ClO\u2082 Technology Shows Clear Virucidal Properties against the Human Coronavirus HCoV-229E at Non-Cytotoxic Doses<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t

Sabina Andreu 1,2,* , In\u00e9s Ripa 1,2, Raquel Bello-Morales 1,2 and Jos\u00e9 Antonio L\u00f3pez-Guerrero 1,2<\/p>

1 Departamento de Biolog\u00eda Molecular, Universidad Aut\u00f3noma de Madrid, Cantoblanco, 28049 Madrid, Spain;\u00a0ines.ripa@cbm.csic.es<\/a>\u00a0(I.R.);\u00a0raquel.bello-morales@uam.es<\/a>\u00a0(R.B.-M.);\u00a0ja.lopez@uam.es<\/a>\u00a0(J.A.L.-G.) 2 Centro de Biolog\u00eda Molecular Severo Ochoa, Spanish National Research Council\u2014Universidad Aut\u00f3noma de Madrid (CSIC-UAM), Cantoblanco, 28049 Madrid, Spain<\/p>