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March 2020 DOI: 10.13140 / RG.2.2.23856.71680

License CC BY-NC-SA 4.0

Project: Toxicity study of chlorine dioxide in solution (CDS) ingested orally

Andreas Ludwig Kalcker co. : Liechtensteiner Verein für Wissenschaft und Gesundheit LI-9491 Ruggel

www.lvwg.org E-mail This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

Chlorine dioxide (ClO2) It has been used for more than 100 years to combat all types of bacteria, viruses and fungi. It acts as a disinfectant, since in its mode of action it turns out to be an oxidant. [1 # BiologicalEfficacyList] It is very similar to the way our own body acts, for example in phagocytosis, where an oxidation process is used to eliminate all kinds of pathogens. Chlorine dioxide (ClO2) It is a yellowish gas that, to date, is not included in the conventional pharmacopoeia as an active ingredient, although it is used in a mandatory way to disinfect and preserve blood bags for transfusions.[2 # Alcide studies on blood disinfection] It is also used in most of the bottled waters suitable for consumption, since it does not leave toxic residues; In addition to being a gas that is very soluble in water and evaporates from 11ºC. 

The recent Covid-19 coronavirus pandemic demands urgent solutions with alternative approaches. Therefore, chlorine dioxide (ClO2) in aqueous solution at low doses promises to be an ideal, fast and effective solution for the elimination of this virus. Too many times it happens that the solution is in the simplest way. The approach is as follows: on the one hand we know that viruses are absolutely sensitive to oxidation and on the other, if it works in human blood bags against viruses such as HIV and other pathogens, why wouldn't it work organically against the coronavirus?

1.- Chlorine dioxide eliminates viruses through the selective oxidation process in a very short time. It achieves this through the denaturation of the capsid proteins, and subsequently oxidizes the genetic material of the virus, disabling it. 

The application of chlorine dioxide (ClO2) orally or even parenterally is a totally new approach that has been studied by Andreas Ludwig Kalcker for more than thirteen years with a result of three pharmaceutical patents for parenteral use. It can be produced by any pharmacy as a magisterial preparation and has been used in a similar way to (DAC N-055) in the old German Drug Code as “Natrium Chlorosum” since 1990.

Until now, only solutions based on vaccines have been proposed, which result in extremely slow and risky processes, since they always require sufficient energy reserves that a body affected with the disease cannot provide. The great advantage of chlorine dioxide (ClO2) is that it works for any viral subspecies and there is no possible resistance to this type of oxidation. [# 3 Investigation on virucidal activity of chlorine dioxide] Let's not forget that this substance has been used for 100 years in wastewater without generating any type of resistance.

2.- There is already scientific evidence that chlorine dioxide is effective in coronavirus SARS-CoV-2 a base virus COVID-19 [SARS Fact Sheet, National Agricultural Biosecurity Center, Kansas State University] and in the Coronavirus family in general · [Chlorine Dioxide, Part 1 A Versatile, High-Value Sterilant for the Biopharmaceutical Industry, Barry Wintner, Anthony Contino, Gary O'Neill. BioProcess International DECEMBER 2005.] It has also been shown to be effective in human coronavirus[# 4 BASF Aseptrol document]and in animals such as dogs, known as canine respiratory coronavirus, or cats, including feline enteric coronavirus (FECV) and the better known feline infectious peritonitis virus (FIPV), since it denatures the capsids by oxidation, inactivating the virus in a short time [2-log 4.2 / 4-log 25.1 Source USEPA 2003 WHO Guidelines for drinking water Quality]

Pharmacology. 2016; 97 (5-6): 301-6. doi: 10.1159 / 000444503. Epub 2016 Mar 1.

Inactivation of Airborne Bacteria and Viruses Using Extremely Low Concentrations of Chlorine Dioxide Gas.

It should be noted that ingesting chlorine dioxide is a completely new antiviral approach as it is an oxidant and is able to eliminate any subspecies or virus variation by combustion.[6 # ClO2 is a size selective biocide] Given the emergency situation in which we currently find ourselves with Covid-19, the oral use of ClO2 is considered immediately through a protocol already known and used. 

3.- ToxicityThe biggest problems with drugs in general are due to their toxicity and side effects. New studies demonstrate its viability.[7 # New Clo2 safety evaluation 2017] Although the toxicity of chlorine dioxide in case of massive inhalation is known, there is not a single clinically demonstrated death even at high doses by oral ingestion.[8 # Controlled Clinical Evaluations of Clo2 in Man] The lethal dose (LD50, acute toxicity ratio) is considered to be 292 mg per kilo for 14 days, where its equivalent in a 50 kg adult would be 15.000 mg administered for two weeks of a gas dissolved in water (something almost impossible).[9 # toxicity of clo2 and chlorite ions].

The oral sub-toxic doses used are around 50 mg dissolved in 100 ml of water 10 times a day, which is equivalent to 0,5 g daily (and therefore only 1/30 of the LD50 of 15 g of ClO2 per day).

As chlorine dioxide dissociates, it breaks down in the human body within a few hours into a negligible amount of common salt (NaCL) and oxygen (O2) within the human body. In addition, venous blood gas measurements have indicated that it is capable of substantially improving the lung oxygenation capacity of the affected patient.

Voluntary: IV application 500 ml NaCl (0,9%) with a concentration of 50 ppm ClO2

Voluntary: IV application 500 ml NaCl (0,9%) with a concentration of 50 ppm ClO2

Voluntary: IV application 500 ml NaCl (0,9%) with a concentration of 50 ppm ClO2


HOW CHLORINE DIOXIDE WORKS AGAINST VIRUSES 

As a general rule, most viruses behave similarly and once they bind to the appropriate host type - bacteria or cell, as the case may be - the nucleic acid component of the virus that is injected takes over afterwards. of the protein synthesis processes of the infected cell. Certain segments of the viral nucleic acid are responsible for the replication of the capsid's genetic material. In the presence of these nucleic acids, the CLO2 molecule becomes unstable and dissociates, releasing the resulting oxygen into the environment, which in turn helps oxygenate the surrounding tissue by increasing mitochondrial activity and thus the response of the immune system.[6 # ClO2 is a size selective biocide].

Nucleic acids, DNA-RNA, consist of a chain of puric and pyrimidine bases, see: guanine (G), cytosine (C), adenine (A) and thymine (T). It is the sequence of these four units along the chain that makes one segment different from another. Guanine base, which is found in both RNA and DNA, is very sensitive to oxidation, forming 8-oxoguanine as a by-product of it. Therefore, when the CLO2 molecule comes into contact with guanine and oxidizes it, it results in the formation of 8-oxoguanine, thus blocking the replication of the viral nucleic acid through base pairing. Although the replication of the protein capsid can continue; the formation of the fully functional virus is blocked by oxidation thanks to CLO2.

The CLO2 molecule has characteristics that make it an ideal candidate for treatment in the clinical setting, since it is a product with a high power of selective oxidation and with a great capacity to reduce acidosis, increasing oxygen in tissues and mitochondria , thus facilitating the rapid recovery of patients with lung diseases.

POSSIBLE PRECAUTIONS AND CONTRAINDICATIONS 

Chlorine dioxide reacts with antioxidants and various acids, so the use of vitamin C or ascorbic acid is not recommended during treatment, as it nullifies the effectiveness of chlorine dioxide in eliminating pathogens (the antioxidant effect of one prevents the selective oxidation of the other.) Therefore, it is not advisable to take antioxidants during the days of treatment. Stomach acid has been shown not to affect its effectiveness. In the cases of patients on Warfarin treatment, they should constantly check the values ​​to avoid cases of overdose, since chlorine dioxide has been shown to improve blood flow.

Although chlorine dioxide is very soluble in water, it has the advantage that it does not hydrolyze, so it does not generate toxic carcinogenic THMs (trihalomethanes) such as chlorine. It also does not cause genetic mutations or malformations.

A protocol has been developed by which a solution of this compound can be taken orally and intravenously. 

Legal bases for the Application immediately:

* In any case, the respective national legislation and, in particular, its provisions for use in case of national emergencies must be observed 

DECLARATION OF THE HELSINKI WORLD MEDICAL ASSOCIATION


Abstract:

Ethical principles for medical research on human beings.

Adopted by the 18th General Assembly of the WMA, Helsinki, Finland, June 1964, and amended by the Committee:

64th General Assembly of the WMA, Fortaleza, Brazil, October 2013

General principles

  1. The Geneva Declaration of the World Medical Association links the doctor with the formula "to watch over my patient's health first and foremost", and the International Code of Medical Ethics states that: "The doctor must consider the best for the patient when get medical attention ”. 

  1. The duty of the doctor is to promote and ensure the health, well-being and rights of patients, including those who participate in medical research. The knowledge and conscience of the doctor must be subordinated to the fulfillment of this duty. 

  1. The progress of medicine is based on research, which must ultimately include studies in humans.

…… ...

Unproven interventions in clinical practice 

  1. When proven interventions do not exist in the care of a patient or other known interventions have proven ineffective, the doctor, after seeking expert advice, with the informed consent of the patient or an authorized legal representative, may allow himself to use unproven interventions, if, in his opinion, this gives some hope of saving life, restoring health or alleviating suffering. Such interventions should be further investigated in order to assess their safety and efficacy. In all cases, this new information must be recorded and, when appropriate, made available to the public.

source: 8/9 © World Medical Association, Inc. 

List of efficacy in pathogens (referenced)

Virus

Adenovirus Type 40 6

Calicivirus 42

Canine Parvovirus 8

Coronavirus3

Feline Calici Virus 3

Foot and Mouth disease 8

Hantavirus 8

Hepatitis A, B & C Virus 3,8

Human coronavirus8

Human Immunodeficiency Virus 3

Human Rotavirus type 2 (HRV) 15

Influenza A22

Minute Virus of Mouse (MVM-i) 8

Mouse Hepatitis Virus spp. 8

Mouse Parvovirus type 1 (MPV-1) 8

Murine Parainfluenza Virus Type 1 (Sendai) 8

Newcastle Disease Virus 8

Norwalk Virus 8

Poliovirus 20

Rotavirus 3

Severe Acute Respiratory Syndrome (SARS) coronavirus 43 

Sialodscryoadenitis Virus 8

Simian rotavirus SA-11 15

Theiler's Mouse Encephalomyelitis Virus 8

Vaccinia Virus 10

Bacteria

Blakeslea trispora 28 

Bordetella bronchiseptica 8

Brucella suis 30

Burkholderia spp. 36

Campylobacter jejuni 39

Clostridium botulinum 32

Clostridium difficult 44

Corynebacterium bovis 8

Coxiella burneti (Q-fever) 35

  1. coli spp .1,3,13

Erwinia carotovora (soft rot) 21

Franscicella tularensis 30

Fusarium sambucinum (dry rot) 21

Helicobacter pylori 8

Helminthosporium solani (silver scurf) 21

Klebsiella pneumoniae 3

Lactobacillus spp. 1,5

Legionella spp. 38,42

Leuconostoc spp. 1,5

Listeria spp. 1,19

Methicillin-resistant Staphylococcus aureus 3

Mycobacterium spp. 8,42

Pediococcus acidilactici PH31

Pseudomonas aeruginosa 3,8

Salmonella spp. 1,2,4,8,13

Shigella 38

Staphylococcus spp. 1,23

Tuberculosis 3

Vancomycin-resistant Enterococcus faecalis 3

Vibrio spp. 37

Multi-Drug Resistant Salmonella typhimurium 3

Yersinia spp. 30,31,40

Bacterial spores

Alicyclobacillus acidoterrestris 17

Bacillus spp. 10,11,12,14,30,31

Clostridium. sporogenes ATCC 1940412

Geobacillus stearothermophilus spp. 11,31

Bacillus thuringiensis 18

OTHER

Beta Lactams 29

Amplicons 46

Volatile organic compounds (VOCs) 47

PROTOZOA

Chironomid larvae 27

Cryptosporidium 34

Cryptosporidium parvum Oocysts 9

Cyclospora cayetanensis Oocysts 41

Giardia 34

Alternaria alternata 26

Aspergillus spp. 12,28

Botrytis species 3

Candida spp. 5, 28

Chaetomium globosum 7

Cladosporium cladosporioides 7

Debaryomyces etchellsii 28

Eurotium spp. 5

Fusarium solani 3

Lodderomyces elongisporus28

Mucor spp. 28

Penicillium spp. 3,5,7,28

Phormidium boneri3

Pichia pastoris 3

Poitrasia circinans 28

Rhizopus oryzae 28

Roridin A33

Saccharomyces cerevisiae 3

Stachybotrys chartarum 7

Verrucarin A 33

Biofilms 4 5


REFERENCES

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  2. Decontamination of produce using chlorine dioxide gas treatment, Richard Linton, Philip Nelson, Bruce Applegate, David Gerrard, Yingchang Han and Travis Selby.
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Barbara Dallap, Donald Munro, and Kym Faylor. Applied Biosafety, 11 (3) pp. 144-154 © ABSA 2006

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presentation. 19th European Congress of Clinical Microbiology and Infectious Diseases, Helsinki, Finland, 16 - 19 May 2009.

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