Covid-19 Protocols

Summary of the intervention protocol

Precautions and contraindications:


  1. The efficacy of chlorine dioxide is nullified when combined with vitamin C and other antioxidants in killing pathogens due to its nature as an oxidising agent.

  2. Allow 1 hour between taking medication and 30 minutes between meals.

  3. The concentrated CDS should be stored refrigerated, at a temperature below 11°C, and protected from UV light.

  4. Due to its nature as an oxidising agent slightly corrosive to metals, it should be taken into account when storing and washing material.

  5. Direct contact with mucous membranes in concentrate form may be too aggressive, so dilute to 50 mg/l (0.005%) with physiological saline solution.

  6. CDS in concentrated form may bleach fabrics due to its oxidising nature.

  7. Do not inhale in concentrated doses due to lung toxicity.

  8. For patients being treated with Warfarin, values should be constantly checked to avoid overdose, as chlorine dioxide has been shown to improve blood flow.

Composed of the following sub-protocols according to application:


  1. Hand and surface disinfection: Protocol D (with >1000 ppm ClO2).
  2. Prevention (health care + asymptomatic patients): Protocol C. 10 intakes.
  3. Preventing contagion between patients and healthcare personnel: Protocol H.
  4. Acute infection: F + C protocol.
  5. Critical cases: protocol Y + C (2h spacing). Protocol C = CDS

This protocol is used as a preventive measure for both healthcare workers and asymptomatic patients.


  1. Dilute 10 ml of concentrated CDS at 3000 ppm in 1 litre of water.
  2. Take 10 intakes, approximately one every hour, until the bottle is finished.
  3. In case of severe or life-threatening illness, the dosage could be gradually increased up to 30 ml CDS per litre of water.

Protocol DC = Dermatological contact

DC Dermatological Contagio (for protection against contagion). Dilute 1 part CDS 3000 with 3 parts saline solution in a spray bottle. After contact with sick people, it can be sprayed into the mouth, nose and eyes to prevent infection in this way. This protocol was very effective for clinical staff during Covid-19. In sensitive cases such as use on mucous membranes, the concentration is lowered to 1:10 in saline. This protocol is used to disinfect skin and objects at risk of infection. It involves the use of a spray atomiser filled with concentrated CDS, 1000 to 2000 ppm (which is equivalent to 0.1 to 0.2% ClO2).


  • Apply the spray directly to the desired area and rub in gently, using it as if it were a hydroalcoholic gel. For sensitive areas (such as eyes and mucous membranes), it is necessary to dilute the concentration with water or saline to a concentration of approximately 50 ppm (sufficient to inactivate pathogens).

Protocol F = Frequent

This protocol is used to combat acute viral and bacterial infections:

Protocol F = 10 ml CDS (0.3%=3000 ppm) 0.5 litre water 8 intakes over 2 hours.

This protocol is highly recommended for sudden cases of discomfort, such as poisoning or unknown bacterial or viral illnesses, and has saved many lives during the pandemic. It is important that the shots are taken every 15 minutes and no closer together, as pathogens reproduce exponentially. A timer, such as a telephone or kitchen timer, can be used to ensure that no more than 15 minutes elapses between feedings. This can be repeated up to 3 times a day in severe cases.


  1. Take 1 ml of CDS every 15 minutes, for 1 hour and 45 minutes, in eight doses, for a total of 8 ml of CDS. Dissolve each 1 ml of CDS (0.3%) in 100 ml of water.
  2. You can add 8 ml of concentrated CDS (0.3%) to a one-litre bottle of water and divide the bottle into 8 equal parts, marking lines, and then drink one mark every fifteen minutes.
  3. Depending on the severity, protocol F can be performed once or twice a day:
  • In the case of two sessions: do it in the morning and in the afternoon (at least 2 hours apart).
  • If done once, continue with protocol C for the rest of the day.

Protocol H = Room

Protocol to avoid contagion or lung problems in rooms: Protocol H is effective for all types of lung conditions and its use is safe as it is supported by peer-reviewed scientific studies [Ogata et al.] 


Procedure: To implement it, place 10-50 ml of CDS depending on the size of the room undiluted in a dry, preferably opaque glass in the bedroom. There, the CDS will evaporate slowly and its effectiveness will be higher if it is placed at a distance of 1-2 metres from the sick person. In warmer environments, evaporation is faster. It is important to note that the characteristic yellow colour of the CDS fades over time and should be replaced when this happens.


It is essential to take precautions to avoid direct inhalations as these are not recommended for safety reasons. Only experienced physicians may do so under strict supervision of the patient and using minimal doses (2-3 drops of CDS) in an inhaler. If chlorine dioxide is inhaled in large quantities and in excess, it can cause serious respiratory problems by occupying the alveoli of the lungs;


Protocol Y = Abbreviated Injection (for doctors only)

  1. Protocol Y consists of using 5 ml of CDS (0.3% = 3000 ppm) per 500 ml of 0.9% NaCl saline solution intravenously over 5 hours.
  2. Venous blood gas analysis can be performed before and after intravenous treatment to determine the efficacy of the dose.
  3. It is recommended to use isotonic physiological NaCl (0.9%) or Ringer’s solution without lactate.
  4. The pH shall be adjusted to 7.6 by the addition of 1-2 ml of 8% injectable sodium bicarbonate solution for buffering to avoid phlebitis.
  5. The standard dose is 5 ml of chlorine dioxide electrolyte (CDE) at 3000 ppm in 500 ml of saline over a period of 5 hours.
  6. A continuous infusion pump can be used for a precise and timely drip.
  7. The standard duration of treatment is 4-6 consecutive days in severe acute cases or twice a week in chronic cases.
  8. Adequate post-puncture compression is recommended to prevent bleeding.
  9. Treatment with oral and/or rectal CDS can be continued two hours after intravenous application.
  10. In critically ill or intubated patients, a slow drip of CDI adjusted to pH 7.6 can be applied for 6-8 hours.

From: Liechtensteiner Verein für Wissenschaft und Gesundheit Author: Andreas Ludwig Kalcker,  Eduardo Insignares M.D., Blanca Bolaños M.D. , Alejandro Merino, Email: